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Xue Gou, Seminar, 3:00 PM, Nov. 14, 2014

Published: November 9, 2014

Xue Gou

Department of Mechanical and Biomedical Engineering, City University of Hong Kong


Topic:

Probing the Functional Mechanism of Cell-to-Cell Interaction and Cell Migration with Optical Tweezer-Based Cell Manipulation Tool


Abstract:

Cell-to-cell interaction and cell migration play crucial roles in a variety of physiological and pathological processes. However, the understanding of individual cell mechanisms at a fundamental and integrated level remains elusive thus far. Methods that can specifically and accurately control cell interaction and migration at the single-cell level are lacking.


In this talk, a cell manipulation system, which integrates optical tweezers and nanotechnology, is developed to allow the functional mechanisms of cell-to-cell interactions and cell migration to be tested and probed. A new approach that combines optical tweezers and fluorescence microscopy technology is proposed to manipulate cell adhesion for cell-to-cell interaction study. Also, a unique method that can quantitatively measure the cell protrusion force during cell migration is developed based on the optical tweezers experiment platform.


Biography:

Xue Gou was born in Sichuan Province, China, in 1987. She received her Bachelor degree in Measurement and Control technology and Instrument from Sichuan University, Sichuan, China, in 2009 and the Ph.D. degree in the Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, in 2014. She is now a Senior Research Associate in City University of Hong Kong. Her current research interests include cell-to-cell interactions and cell migration study based on the using of optical tweezers and microfluidic technologies.



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